Publications

Integration of 3D-printed micromixers and spray drying for pulmonary delivery of antimicrobial microparticles

Anaya Bryan J, Kara Aytug, Raposo Rafaela, Tirado Diego F, Lalatsa Aikaterini, González-Burgos Elena, Serrano Dolores R

International Journal of Pharmaceutics Vol 674 (2025)

https://doi.org/10.1016/j.ijpharm.2025.125493

Continuous manufacturing of nanomedicines using 3D-printed microfluidic devices

Kara Aytug, Ongoren Baris, Anaya Meza Bryan Javier, Lalatsa Katerina, Serrano Dolores R

Applied Materials Today Vol 43 (2025)

https://doi.org/10.1016/j.apmt.2025.102672

Targeted oral fixed-dose combination of amphotericin B-miltefosine for visceral leishmaniasis

Fernández-García Raquel, Walsh David, O'Connell Peter, Domingues Passero Luiz Felipe, de Jesus Jéssica A, Laurenti Marcia Dalastra, Dea-Ayuela María Auxiliadora, Ballesteros M Paloma, Lalatsa Aikaterini, Bolás-Fernández Francisco, Healy Anne Marie, Serrano Dolores R

Molecular Pharmaceutics Vol 22, pp. 1437–1448 (2025)

https://doi.org/10.1021/acs.molpharmaceut.4c01133

Dicentrine purified from the leaves of Ocotea puberula controls the intracellular spreading of L. (L.) amazonensis and L. (V.) braziliensis amastigotes and has therapeutic activity as a topical treatment in experimental cutaneous leishmaniasis

Adriana Jesus Jéssica, Araujo Flores Gabriela V, da Silva Souza Dalete Christine, Costa Tristão Daniela, Serrano Dolores R, Lalatsa Aikaterina, Laurenti Márcia Dalastra, Ghilardi Lago João Henrique, Gomes Ferraz Humberto, Pereira da Silva Rosana, Domingues Passero Luiz Felipe

Microorganisms Vol 13 (2025)

https://doi.org/10.3390/microorganisms13020309

Heparin-azithromycin microparticles show anti-inflammatory effects and inhibit SARS-CoV-2 and bacterial pathogens associated to lung infections

Anaya Bryan J, D'Angelo Davide, Bettini Ruggero, Molina Gracia, Sanz Amadeo, Dea-Ayuela Maria Auxiliadora, Galiana Carolina, Rodriguez Carmina, Tirado Diego F, Lalatsa Katerina, Gonzalez-Burgos Elena, Serrano Dolores R

Carbohydrate Polymers Vol 348 (2025)

https://doi.org/10.1016/j.carbpol.2024.122930

Active targeting of nanomedicines

Serrano Dolores R, Kara Aytug, Ramirez Bianca I, Ramirez Irving O, Ongoren Baris, Lalatsa Aikaterini

Fundamentals of Pharmaceutical Nanoscience (2024) (2024)

https://doi.org/10.1007/978-3-031-59478-6_14

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Professional Activities

PhD Examiner - Universidad Complutense Madrid

Examiner

7/3/2025

National Science Center (External organisation)

Advisor

28/11/2024

Fundamentals of Pharmaceutical Nanoscience 2nd Edition (Hardcover)ISBN:9783031594779, 3031594770Book Editor (Event)

Peer reviewer

24/9/2024

Cancer Research UK CRUK (External organisation)

Advisor

24/6/2024

Nanoenabled Hydrogels for Blepharoplastic Surgery

Speaker

19/4/2024

Molecular Legos for Targeted Brain Delivery

Speaker

14/3/2024

More professional activities

Projects

Understanding biofilm formation on medical device surfaces

Serrano, Dolores R. (Principal Investigator) Lalatsa, Aikaterini (Co-investigator) Ramage, Gordon (Co-investigator)

Implantation of medical devices, such as orthopaedic implants, accounts for a significant proportion of hospital-acquired infections. These infections are notoriously difficult to treat because they are primarily caused by biofilms. There is limited knowledge about biofilm formation on implanted devices, and existing in vitro models can not accurately replicate the physiological microenvironment, leading to a shortage of animal-free models for testing antimicrobial and antibiofilm strategies. No previous attempts to mimic medical device-biofilm interfaces are described in the literature as most of them only model the bone structure or the biofilm microenvironment, but not the complex interface between the two. This project aims to develop an in vitro 3D-printed organ-on-a-chip model that mimics the physiological human bone microenvironment in terms of osseointegration and biofilm growth on the surface of orthopaedic medical devices after implantation. The acetabular component of a hip replacement will be used as a proof of concept model. Novel methods to understand how bacterial and fungal biofilms (S. aureus and C. albicans) are formed on the surface of implanted medical devices will be developed allowing the testing of the efficacy of different antimicrobials. Validation of the methodology using in vivo preclinical PJI models will be carried out. The implementation of these novel 3D in vitro methods in clinical settings could significantly improve the management of prosthetic joint infections (PJIs) guiding the rational selection of antimicrobial drugs.

01-Jan-2025 - 31-Jan-2027

Development of a oligonucleotide nanoparticle

Lalatsa, Aikaterini (Principal Investigator)

14-Jan-2024 - 21-Jan-2024

Engineered silks for surgical wounds

Lalatsa, Aikaterini (Principal Investigator) Connolly, Patricia (Co-investigator)

02-Jan-2023 - 30-Jan-2027

Manufacture and release of Lucentis Drug Product

Lalatsa, Aikaterini (Principal Investigator)

02-Jan-2023 - 28-Jan-2025

Qualified persons training programme 23-25

Lalatsa, Aikaterini (Principal Investigator) Young, David (Co-investigator)

extension to K230850-101

01-Jan-2023 - 31-Jan-2025

Aprender a emprender entre los estudiantes universitarios de posgrado

Serrano, Dolores R (Principal Investigator) Lalatsa, Aikaterini (Co-investigator)

Innovation in Teaching; Developing Entrepreneurship Skills of Post-graduate students

01-Jan-2022 - 30-Jan-2023

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